In animal tests, the experimental vaccine successfully

In animal tests, the experimental vaccine successfully

based vaccines challenge big pharma for

NEW Canada Goose sale YORK (Reuters) Two tiny companies are Canada Goose Online preparing to challenge some of the world largest drug makers in the battle for dominance cheap Canada Goose in the $3 billion global market for influenza vaccines, canada goose coats on sale armed with little more than tiny tobacco plants.

cheap Canada Goose A worker inspects the Nicotiana benthamiana plants at Medicago greenhouse in Quebec City in this file photo taken August 13, 2014. REUTERS/Mathieu Belanger/Files cheap Canada Goose

Canada Goose Parka The use of plants to produce life saving pharmaceuticals captured global attention when it was revealed that the Ebola drug ZMapp Canada Goose Coats On Sale is produced in the leaves of tobacco plants. Canada Goose Parka

buy canada goose jacket Even as Ebola cases multiply in West Africa, a far greater market for plant based biopharmaceuticals will likely be influenza vaccines used to fight pandemics, industry experts said. Making vaccines from plants may turn out to be faster and cheaper than current methods which use chicken eggs to grow the virus needed to make the vaccines. buy canada goose jacket

canada goose coats Leading producers such as uk canada goose GlaxoSmithKline Plc and Sanofi SA need six months to produce flu Canada Goose Jackets vaccine once scientists identify the canada goose uk shop dominant virus expected to circulate during flu season. Vaccine production from tobacco plants by Quebec City based Medicago or Bryan, Texas based Caliber Biotherapeutics could do it in weeks. and CEO of Texas A Health Science Center in canada goose uk black friday Bryan. facilities tasked by the government with being ready to produce and deliver 50 million doses of flu vaccine in just 12 weeks. It is working with Caliber toward that goal. canada goose coats

If the upstarts succeed, Canada Goose Outlet they will make little difference to the tobacco industry, which regards even a $3 billion market as marginal. But they could threaten the pharma giants that dominate flu vaccine production canada goose factory sale or be gobbled up canada goose uk outlet by them.

Canada Goose Outlet Medicago is now testing its flu vaccine in elderly people, who are most at risk, and plans to launch a large canada goose clearance sale human trial in 2016. hope to hit the market in 2019, said Jean Luc Martre, director of government affairs. Canada Goose Outlet

canada goose store Tobacco plants could be enlisted in the fight against flu even Canada Goose online sooner if a pandemic hit. The 50 million canada goose doses that labs like Texas A pledged they be able to produce in a few months can be manufactured in today egg based systems. canada goose store

canada goose black friday sale there is a need for it that requires plant based production, we turn to Caliber, said Giroir, referring to an accelerated vaccine production schedule to counter a flu pandemic. market canada goose store alone, growing the virus in chicken eggs. Usually the doses, which protect against strains that experts predicted the previous February, are ready in time and in sufficient quantity. canada goose black friday sale

canada goose coats on sale But if the strain that appears during flu season was not the one experts forecast, the vaccines might not work. got swine flu and 12,500 died. government to award canada goose black friday sale $400 million in start up funding to three Centers for Innovation in Advanced Development and Manufacturing (CIADMs) to boost biodefense and preparedness for pandemic flu. canada goose coats on sale

canada goose clearance no way you can produce 50 million doses in 12 weeks with current production technology, said Giroir. plant based production could. canada goose clearance

canada goose clearance sale While one chicken egg can produce one or two doses of flu vaccine, canada goose clearance one tobacco plant can produce 50 at a fraction of the cost. canada goose clearance sale

canadian goose jacket The Defense Advanced Research Projects Agency (DARPA), an arm of the Defense Department that funds cutting edge research, is impressed enough with the potential of tobacco plant production systems to have awarded multi million dollar grants to both Medicago and Caliber, and so far the support has paid off. canadian goose jacket

In a 2012 DARPA challenge, Medicago, jointly owned by Philip Morris International and Mitsubishi Tanabe Pharma canadian goose jacket Corp, produced 10 million doses of H1N1 flu vaccine in just a month in tobacco plants inside its sprawling North Carolina greenhouses. In animal tests, the experimental vaccine successfully triggered the production of protective antibodies against H1N1.

Canada Goose Jackets HURDLES AHEAD All the company had to go on was part of the canada goose coats virus genetic sequence. But while in egg based production whole flu viruses are injected into the eggs, where they replicate and form the buy canada goose jacket basis for the vaccine, all that really needed to trigger immunity are the proteins that stud the virus uk canada goose outlet coat. Canada Goose Jackets

canada goose Those proteins, called hemagglutinins, are what the immune system attacks. They can be produced by splicing the hemagglutinin gene into almost any kind of cell; Medicago uses harmless bacteria to carry the hemagglutinin Canada Goose Parka genes into the tobacco plant leaves. canada goose

Technicians at the greenhouses in North canada goose outlet Carolina then soak 36 day old Nicotiana benthamiana plants (cousins of those used for cigarettes) upside down in a liquid containing the Trojan Horse bacteria, explained chief scientist Marc Andre D Through a process called vacuum infiltration, air is drawn out of the leaves and they suck up the bacteria.

canada goose deals After growing in special chambers for a week, the leaf cells are churning out hemagglutinins. Extracted, purified, and combined with other bits of the virus, they form the basis for a vaccine. canada goose deals

Canada Goose online Major vaccine makers are cautious about the new technology. tend to avoid publicly speculating on what future technologies we might embrace, said Robert Perry, a Glaxo spokesman said. Canada Goose online

buy canada goose jacket cheap all of our flu vaccine production is in (chicken) eggs, said Rene Labutat, vice president of manufacturing for Sanofi. we are looking at the recombinant approach, including in mammalian cells, algae, fungi and plants buy canada goose jacket cheap.

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